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to: navigation, search. Image; File history; File links. Structure.svg. antihistamines diphenhydramine and reverse eosinophil survival by enhancing apoptosis.. Diphenhydramine is an antihistamine that competitively inhibits histamine binding at the H1 receptors. Antihistamines do not block the release of histamine. Diphenhydramine is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. In a randomized ADP iPayStatements trial, neither medication was better than placebo in controlling nocturnal cough or improving sleep quality.
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